About 4 results found for searched term "Nrf2 activator-3" (0.128 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42736 | Nrf2 activator-3 | Keap1-Nrf2 |
| Nrf2 activator-3 is a potent Nrf2 activator. | ||
| M8767 | MIND4-17 | Others |
| MIND4-17 is a potent NRF2 (nuclear factor erythroid 2-related factor 2) activator that covalently modifies a critical stress-sensor cysteine (C151) in the BTB domain of the E3 ligase substrate adaptor protein Kelch-like ECH-associated protein 1 (KEAP1), the primary negative regulator of NRF2. | ||
| M29455 | DDO-7263 | Keap1-Nrf2 |
| DDO-7263, a 1,2,4-Oxadiazole derivative, is a potent Nrf2-ARE activator. DDO-7263 upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 induces Nrf2 translocation into the nucleus. DDO-7263 inhibits of NLRP3 inflammasome activation. DDO-7263 exerts anti-inflammatory activity and has the potential for neurodegenerative diseases research, such as Parkinson's disease (PD). | ||
| M42734 | Nrf2 activator-8 | Keap1-Nrf2 |
| Nrf2 activator-8 is a Nrf2 activator (EC50=37.9 nM). | ||
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